Article title
The title should be short and informative. The use of abbreviations and abbreviations, as well as trade (commercial) names, medications, materials, products, equipment, etc. is not allowed.

Author names

Affiliation
The official name of the institution is given, indicating its departmental affiliation, city and country where it is located. If authors from different institutions took part in writing the manuscript, uppercase numbers indicate each author’s affiliation with a particular institution.

Correspondence
For each author, the full last name, first name, patronymic (if any), academic degree and title, place of work, position, postal address with zip code, available telephone number, and email address are indicated. The author responsible for communication with the editors is listed first.

Abstract
The abstract is a source of information independent of the article and should be understandable without reference to the publication itself. The abstract describes the main objectives of the study; explains how the study was conducted without methodological details; summarizes the most important results. For original research, it must be structured (introduction, goals and objectives, methods, results/discussion, conclusion/conclusions). The abstract should contain from 100 to 300 words, it should not contain references to literature, abbreviations and abbreviations, with the exception of units of measurement.

Keywords
Keywords contribute to the indexing of the article in search engines (no more than 8), are placed in order of importance and are separated from each other by a semicolon. Keywords given in Russian and English must correspond in meaning and quantity to each other.

Article title
The English-language name must fully correspond in meaning to the Russian-language name, subject to the rules of the English language.

Author names
The full name must be written in the same way as in previously published foreign works. First-time publishing authors can use the BGN/PCGN transliteration standard. Transliteration - (automatic transliteration in the BSI standard - http://translit.ru/)

Affiliation
The official English name of the institution is indicated. The most complete list of names of institutions and their official English version can be found on the website eLibrary.ru (hyperlink to http://elibrary.ru/defaultx.asp)

Correspondence
For each author, the full last name, first name, patronymic (in transliteration), academic degree and title, place of work, position, postal address with zip code, available phone number, email address are indicated in Latin letters. The author responsible for communication with the editors is listed first.

Abstract
The English version of the article's abstract must be fully consistent in meaning and structure with the Russian version (for original research, contain sections Backgraund, Aims, Materials and methods, Results, Conclusions) and should not be a direct literal translation (tracing paper), the basic rules and stylistics of the English language must be observed , use generally accepted English-language technical terminology.

Keywords
Keywords contribute to the indexing of the article in search engines (no more than 8), are placed in order of importance and are separated from each other by a semicolon. Keywords given in Russian and English must correspond in meaning and quantity to each other.

The text of the manuscript describing the results of the original research should contain the following sections: introduction (relevance), purpose and objectives, materials and methods, results, discussion, conclusion.

Purpose of the study
Reflects the main question, the solution of which required the research

Introduction
The relevance of the research, the scale of the problem being studied (prevalence, morbidity, etc.), indirect effects (social, economic), solved and unresolved aspects of the problem. Each statement of the authors, with the exception of the most well-known ones, must be accompanied by links to sources of information (no more than 3 links for each statement).

Material and methods:

• study design: study object, planned duration, intended medical intervention, methods for testing the hypothesis and evaluating results, description of the randomization procedure),
• eligibility criteria (inclusion, non-inclusion and exclusion from the study),
• conditions of conduct (centers that took part in the study, characteristics of specific social, economic, etc. factors),
• Features of the research implementation:
• duration of the study and information about changes in time intervals;
• features of medical intervention or organizational measures (particularities of the examination and treatment, preoperative preparation, surgical interventions, anesthesia, postoperative management, etc.),
• indicators that allow you to evaluate the results and achievement of the goal of the study (development of complications, biochemical parameters, assessment of quality of life, etc.),
• information on the results of the review of the research protocol by the ethical committee (official name of the ethical committee; number and date of signing of the document; conclusion).
• methods of statistical analysis (developer of a statistical software package, data, sample size calculation, statistical criteria used in data analysis).

When mentioning equipment and drugs, the company and country of manufacture are indicated in parentheses. The journal uses international nonproprietary names of drugs and preparations. Trade names are given in the “Material and Methods” section, indicating the manufacturer and their international nonproprietary (generic) name.

Results
The main additional results of the study are presented with the results of statistical data analysis, illustrations (figures, tables) without duplicating data in the text. The presence or absence of adverse events is noted. All adverse events that occurred during the study (illnesses, injuries, unplanned surgical interventions, etc.) are described, the connection of which with the medical intervention cannot be excluded.
Units of measurement are given in accordance with the International System of Units (SI). Abbreviations, except for generally accepted abbreviations of chemical and mathematical quantities and terms, should be used in exceptional cases and deciphered at the first mention.
Latin names of microorganisms are highlighted in italics; upon first mention, the name is given in full - genus and species (Escherichia coli, Staphylococcus aureus, Streptomyces lividans); upon repeated mention, the generic name is shortened to one letter (E.coli, S.aureus, S.lividans).
The names of genetic elements are given in the three-letter designation of the Latin alphabet in lowercase letters, italics (tet), and the products encoded by the corresponding genetic elements are given in uppercase letters (TET).

Discussion
Discussion includes interpretation of the study results. New important aspects are highlighted and compared with data from other researchers. It is necessary to note the scope of the study and its practical significance. Hypotheses and evidence-based recommendations can be included in the discussion.

Conclusion
The conclusion is presented in the form of a single text, which briefly summarizes the results of previously conducted research (1–3 sentences), sets out the key unresolved aspects of the identified problem (1–3 sentences), the results obtained with an explanation of their contribution to solving the problem (5–7 sentences) , the rationale for the clinical and/or scientific use of the research results is provided.

Source of financing:
If available, indicate the source(s) of funding for the study (for example, “The study was carried out with financial support (financial support) ...".

Conflict of interest:
Indicate the presence of a conflict of interest, that is, conditions and facts that could affect the results of the study (for example, funding from interested individuals and companies, their participation in discussing the results of the study, writing the manuscript, etc.). If there are none, use the following wording: “The authors of this article have confirmed that there is no conflict of interest to report.”

Acknowledgments:
The authors can express gratitude to those whose contribution to the research was not sufficient to be recognized as co-authors, but at the same time is considered significant by the authors (consultations, technical assistance, translations, etc.).

The article contains 2 bibliography sequentially:

1. The list of references for indexing the RSCI (section “Literature”) is drawn up in accordance with GOST R 7.0.5-2008,
2. The list of references for indexing by foreign databases (section “References”) is absolutely consistent in content with the first one, but is formatted in the Vancouver format in the AMA version - http://www.amamanualofstyle.com).
3. In bibliography, each source should be placed on a new line under a serial number.
4. All works are listed in order of citation and NOT in alphabetical order. In the text of the article, bibliographic references are given in square brackets in Arabic numerals.
5. Only published materials are provided (links to Internet resources are allowed).
6. It is advisable to cite contemporary sources published within the last 5-7 years.
7. For each source, it is necessary to indicate the last names and initials of all authors of the cited article. If there are more than 6 co-authors, after the 6th author it is necessary to put the abbreviation “..., etc.” or "..., et al.".
8. The names of English-language journals should be abbreviated in accordance with the catalog of titles in the MedLine database. If the journal is not indexed in MedLine, its full name must be indicated.
9. The name of the domestic journal is given in full.
10. It is not advisable to link to Russian-language articles that do not have an official translation of the title into English. If a link to such a publication is required, in the “References” section, the following format is used: surnames and initials of all authors in Latin, transliteration of the title of the article, name of the Russian-language journal in transliteration (italics), output data - year, volume, number, pages, in in round brackets - the language of publication (In Russ.). The doi of the article (if available) is placed at the end of the bibliographic description.
11. All other Russian-language sources in the “References” section are given in Latin using transliteration. The language of publication (In Russ.) is placed in parentheses.
12. Detailed recommendations for preparing a list of references for indexing by foreign databases can also be found at https://www.nlm.nih.gov/bsd/uniform_requirements.html
13. In all cases where the cited material has a Digital Object Identifier (DOI), it must be indicated at the very end of the bibliographic reference. You should check the availability of the doi of the article at http://search.crossref.org/ or https://www.citethisforme.com.
14. The authors are responsible for the correctness of the data given in the reference lists.

All tables must have a numbered title and clearly marked, understandable columns. These tables should not duplicate the information presented in the text. References to tables in the text are required.

Illustrations (graphs, diagrams, diagrams, drawings) must be made in a separate file and saved along with the applied notes (arrows, signatures, etc.) as an image in *.jpeg, *.bmp, *.gif, and then placed in the manuscript file as a fixed figure.

Photographs, prints of monitor screens (screenshots) and other non-drawn illustrations must not only be inserted into the text of the manuscript, but also uploaded separately in the form of files in *.jpeg, *.bmp, *.gif formats. Image resolution must be >300 dpi. Image files must be given a name corresponding to the number and name of the image in the text.